UniProt accession | P00806 [UniProt] | ||||||||||||||||
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Protein name | Endolysin | ||||||||||||||||
PhaLP type |
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Protein sequence | |||||||||||||||||
Physico-chemical properties (ProtParam) |
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Domains [InterPro] | |||||||||||||||||
Name | Taxonomy ID | Lineage | |
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Phage | Escherichia phage T7 [NCBI] | 10760 | Autographiviridae> Teseptimavirus > Teseptimavirus T7 |
Host |
Escherichia coli [NCBI] |
562 | Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia |
Accession | Protein Name | Phage | |
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UPI0000110627 [UniParc] | D1LVD8 [UniProt] | Endolysin | Escherichia phage T7 [NCBI] |
P00806 [UniProt] | Endolysin | Escherichia phage T7 [NCBI] | |
Q3V7D1 [UniProt] | Endolysin | Enterobacteria phage T7.1 [NCBI] | |
Genbank protein accession | CAA24403.1 [NCBI] | ||||
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Genbank nucleotide accession | V01146.1 [NCBI] | ||||
CDS location |
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CDS | |||||
Description | Category | Evidence (source) | |
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GO:0008270 | zinc ion binding | Molecular function | Inferred from Electronic Annotation (InterPro) |
GO:0008745 | N-acetylmuramoyl-L-alanine amidase activity | Molecular function | Inferred from Direct Assay (UniProtKB) |
GO:0030430 | host cell cytoplasm | Cellular component | Inferred from Electronic Annotation (UniProtKB-SubCell) |
GO:0009253 | peptidoglycan catabolic process | Biological process | Inferred from Electronic Annotation (UniProtKB-UniRule) |
GO:0031640 | killing of cells of another organism | Biological process | Inferred from Electronic Annotation (UniProtKB-KW) |
GO:0032897 | negative regulation of viral transcription | Biological process | Inferred from Direct Assay (UniProtKB) |
GO:0042742 | defense response to bacterium | Biological process | Inferred from Electronic Annotation (UniProtKB-KW) |
GO:0044659 | viral release from host cell by cytolysis | Biological process | Inferred from Direct Assay (UniProtKB) |
EC | Name | Reaction catalyzed | Source | |
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3.5.1.28 | N-acetylmuramoyl-L-alanine amidase. | Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acidresidues in certain cell-wall glycopeptides. |
HAMAP-Rule:MF_04111 PubMed:8171031 |
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pmid | Title | Authors | Publication date |
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15223315 | Multiple roles of T7 RNA polymerase and T7 lysozyme during bacteriophage T7 infection. | Zhang X, Studier FW | 2004 Jul 16 |
14764584 | T7 lysozyme represses T7 RNA polymerase transcription by destabilizing the open complex during initiation. | Stano NM, Patel SS | 2004 Apr 16 |
9192997 | Mechanism of inhibition of bacteriophage T7 RNA polymerase by T7 lysozyme. | Zhang X, Studier FW | 1997 May 30 |
8171031 | The structure of bacteriophage T7 lysozyme, a zinc amidase and an inhibitor of T7 RNA polymerase. | Cheng X, Zhang X, Pflugrath JW, Studier FW | 1994 Apr 26 |